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Current data indicated that this question still cannot be conclusively answered as both autophagy and necroptosis are considered to have a Janus-faced role in tumorigenesis and cancer treatment

For example, a clinical trial (NCT05032014) is evaluating whether the probiotic Probio-49 can augment the efficacy of PD-1 inhibitors in the treatment of liver cancer

114 In the meantime, chimeric antigen receptor (CAR)-modified immune cells and oncolytic viruses are also under investigation

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doi:10.3390/ani10020326 21 Fishman G, Singer P